We are interested in understanding mechanisms that allow biological stress-sensors to detect danger signals and initiate highly coordinated coping-responses by assembling into higher order molecular assemblies.
Matyszewski, M., Morrone, S.M., and Sohn J. Digital signaling network drives the assembly of the AIM2-ASC inflammasome. (2018). PNAS 115: E1963-72
Antiochos, B., Matyszewski, M., Sohn J., Casciola-Rosen, L., and Rosen, A. IFI16 filament formation in salivary epithelial cells shapes the anti-IFI16 immune response in Sjögren’s Syndrome. Journal of Clinical Investigation, Insight. (2018) 3(18)
Hooy, R.M. and Sohn, J. The allosteric activation of cGAS underpins its dynamic signaling landscape. (2018) eLife e39984
Matyszewski, M., Zheng, W., Lueck, J., Antiochos, B, Egelman, E*., and Sohn, J*., The cryo-EM structure of the NLRC4CARD filament provides insights into how symmetric and asymmetric assemblies are utilized in inflammasome signaling. (2018) Journal of Biological Chemistry in press *: co-corresponding authors.